Background and Objectives: Cardiovascular diseases (CVDs) impose great burden on the health systems worldwide. The prevention of CVDs depends on the correct information about the perveance/incidence of them and their determinants in the community and population-based studies are the most accurate ways for obtaining these data. The objective of this study is to determine the prevalence of the classic risk factors of CVDs among healthy adult residents of Tehran and their changes through a 10-year follow-up in Tehran, the capital of Iran. This article presents the study protocol. Methods: Heart Assessment and Monitoring in RAjaie Hospital, is a population-based study conducted in Rajaie Cardiovascular Medical and Research Center, the largest tertiary care hospital for CVDs in Tehran. It consists two phases: A survey and a prospective cohort. People between 30 and 75 years of age, without known CVDs, invite through a multistage random sampling process. They will assess for the CVD risk factors, laboratory indices, electrocardiography and echocardiography features, diet, physical activity levels, psychological aspects, and peripheral vascular diseases. All the participants will be followed for 10 years and the changes in the above-mentioned factors and incidence of CVDs assessed. Discussion: It is expected that through obtaining valid, population-specific data, the information for policy making and efficient management of CVDs in Iranian people be provided.

Introduction: It is important to have a strong appropriate tool for measuring, evaluating, and understanding the nature and consequences of chronic stresses on caregivers of patients with heart failure (HF). The purpose of this study is the assessment of the validity and reliability of the questionnaire for evaluating the burden on caregivers of patients with HF. Methods: In order to assess the burden of caregivers of patients with HF, the Caregiver Burden Questionnaire for Heart Failure version 3 (CBQ-HF, version 3) was used. After translation and back translation, the questionnaire was provided to 20 caregivers, and after 2 weeks, the same caregivers refilled the questionnaire; so that, we could measure its reliability by calculating Cronbach's alpha. Face validity and content validity were also obtained at this stage. Finally, the questionnaire was provided to eighty caregivers; hence, the total number of one hundred caregivers completed the questionnaire. Results: From a total of 100 collected questionnaires, 68 of participants were male and 32 of participants were female. The mean ± standard deviation of emotional burden on the patient's caregivers was 46 ± 10 and the median of the physical, social, and living pattern burden was 14, 4, and 13, respectively. The test–retest reliability showed high internal consistency (Cronbach's alpha: 94%). Conclusion: This study approved the Persian version of CBQHF questionnaire as a standard and valid tool in Persian language, which can be used among caregivers of patients with HF in order to examine their problems and to plan for improving their quality of life.

Aim: The aim is to study the clinical, social, biochemical, and angiographic profile of youth (under 35 years) with familial premature coronary artery disease (PCAD). Subjects and Methods: The PCAD registry is a prospective ongoing descriptive observational study of Indians aged below 40 years with coronary artery disease (CAD) which was started on April 1, 2017. Of 3450 patients registered in the PCAD registry till date, 1628 patients were aged 35 years or younger. Of these 1628 patients, 218 satisfied entry criteria. The entire clinical and angiographic profile of these patients was documented. The distribution of different lipid profile parameters was visualized by nonparametric density plot. The data were analyzed by statistical software R version 3.5.0. Results: Of 3450 patients registered in the PCAD registry till date, 1628 patients were aged ≤ 35 years. Two hundred and eighteen out of these 1628 patients (13.39%) belonged to the study group for this particular study. The mean age of all patients under the PCAD registry was 30.44 years, and 201 (92.2%) were males. 106 (48.62%) were smokers. Twenty-nine patients (13.33%) of them were diabetic. The most common index presentation of CAD in familial PCAD was with ST-elevation myocardial infarction (STEMI; 112 patients – 51.37%) and unstable angina/non-STEMI (58 patients – 26.6%). Forty-eight patients (22.01%) presented with evolved MI. Conclusions: Almost 14% of coronary events in younger age (under 35 years) were attributable to family history of CAD. Family history of CAD can be used as a criterion to select younger age population to perform targeted screening for cardiovascular diseases.

Introduction: Clinical registries are a targeted way of data collection aimed at finding a solution to a specific clinical inquiry. The present report introduces the Rajaie Cardiovascular, Medical and Research Center percutaneous coronary intervention (RHC-PCI) Registry. The primary objectives of the RHC-PCI Registry consist of monitoring different complex PCI procedures and their mutual impact on interventional cardiology programs. Methods: RHC is a large and well-known cardiovascular tertiary center in Iran. The RHC-PCI Registry was first launched in 2015, since which time it has collected >5000 parameters regarding the baseline, clinical, and procedural characteristics of various PCI procedures. Noncomplex coronary interventions, bifurcation stenting, left main interventions, chronic total occlusion (CTO) PCI, and bypass graft interventions comprise the major categories gathered by the RHC-PCI Registry. The main registry outcomes are comprised in-hospital mortality, major adverse cardiovascular events, vascular access site complications, and 6-month all-cause mortality. Results: In this primary report, we elaborate on the principal infrastructure of the RHC-PCI Registry and present a synopsis of the registry scope. During the first 40 months of the registry, 11,005 patients underwent PCI. The acute coronary syndrome was reported in 5043 (45.8%) patients. Bifurcation stenting, left main interventions, CTO PCI, and bypass graft interventions were performed in 1679 (15.2%), 236 (2.1%), 946 (8.5%), and 764 (6.9%) patients, respectively. The preferred access site was the femoral artery (n = 6614, 60%), and drug-eluting stents were deployed in 9230 (83.8%) patients. In-hospital mortality in the total registry data was reported in 104 (0.9%) patients. Conclusions: This report introduces the RHC-PCI Registry, its primary objectives, infrastructure, and preliminary results (the 3-year outcome).

Arterial tortuosity syndrome (ATS) is a very rare autosomal recessive disease which results from mutations of the SLC2A10 gene. In this article, we describe the results of vascular imaging of an adult patient with ATS who was presented with pulmonary hypertension and after a complete evaluation, he was a candidate for interventional balloon angioplasty. Our patient is one of the very limited numbers of list patients in the studies for whom percutaneous balloon angioplasty performed successfully.