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Year : 2016  |  Volume : 5  |  Issue : 1  |  Page : 12

Galectin-3 serum levels are independently associated with microalbuminuria in chronic heart failure outpatients

1 Department of Cardiothoracic, Cardiology Unit, Policlinic University Hospital, Bari, Italy
2 DEA Department, Cardiology Unit, San Filippo Neri Hospital, Rome, Italy
3 Department of Emergency and Organ Transplantation, School of Cardiology, University of Bari, Bari, Italy
4 Cardiology Unit, Hospital Department, Chioggia ULSS 14, Chioggia, Italy
5 Cardiology Unit, Cardiology Department, San Paolo Hospital, Bari, Italy
6 Department of Diagnostic Pathology, Bioimages and Public Health, Policlinic University Hospital, Bari, Italy
7 Clinical Pathology Unit, University of Bari, Bari, Italy

Correspondence Address:
Massimo Iacoviello
Department of Cardiothoracic, Cardiology Unit, Policlinic University Hospital, Bari
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Source of Support: None, Conflict of Interest: None

DOI: 10.5812/cardiovascmed.28952

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Background: Galectin-3 (Gal-3) is a novel biomarker reflecting inflammation status and fibrosis involving worsening of both cardiac and renal functions. Objectives: The aim of this study was to evaluate the relationship between Gal-3 serum levels and microalbuminuria in a group of chronic heart failure (CHF) outpatients. Patients and Methods: We enrolled CHF outpatients having stable clinical conditions and receiving conventional therapy. All patients underwent clinical evaluation, routine chemistry analysis, echocardiography, and evaluation of the urinary albumin/creatinine ratio (UACR). Results: Among the patients enrolled, 61 had microalbuminuria (UACR, 30-299) and 133 normoalbuminuria (UACR, < 30). Patients with normoalbuminuria showed significantly higher levels of Gal-3 than those without (19.9 ± 8.8 vs. 14.6 ± 5.5 ng/mL). The stepwise regression analysis indicated that Gal-3 was the first determinant of microalbuminuria (odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02 - 1.14, P = 0.012), followed by diabetes (OR 2.14; 95% CI: 1.00 - 4.57; P = 0.049) and high central venous pressure (OR 2.80; 95% CI: 1.04 - 7.58; P= 0.042). Conclusions: Our findings indicate an independent association between Gal-3 levels and microalbuminuria, an early marker of altered renal function. This suggests the possible role of Gal-3 in the progression of cardiorenal syndrome in CHF outpatients.

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