Research in Cardiovascular Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 3  |  Page : 69--75

Modulation of plasma triglycerides concentration by sterol-based treatment in subjects carrying specific genes


Ismael San Mauro Martin1, Javier Andrés Blumenfeld Olivares2, Elena Garicano Vilar1, María José Ciudad Cabañas3, Luis Collado Yurrita3 
1 Research Centers in Nutrition and Health, Madrid, Spain
2 Pediatric Unit, El Escorial Hospital, San Lorenzo de El Escorial, Madrid, Spain
3 Department of Medicine, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain

Correspondence Address:
Dr. Ismael San Mauro Martin
Research Centers in Nutrition and Health, Paseo De La Habana, 43, Madrid 28036
Spain

Introduction: Genetic load may indirectly influence on cardiovascular risk. This work aimed to analyze the influence of polymorphisms (APOA5 C56G-Ser19Trp, Prothrombin-G20210A, F5 Arg506Gln, MTHFR-C677T, LIPC-C-514T, LPA-I4300M, PPAR_ALPHA-L162V, APOA5-1131T > C, APOE-APOE2/3/4, and APOE-APOE2,3,4) in plasma triglyceride (TG) levels of patients ingesting plant sterols. Materials and Methods: Double-blind, crossover, controlled clinical trial was performed in 45 individuals (25 women). About 2.24 g sterols in milk and placebo milk were ingested daily during 3 weeks each, separated by a 2-week washout period. Blood draws and saliva genomic DNA was extracted. Results: APOA5-C56G-Ser19Trp, MTHFR-C677T, and PPAR_ALPHA-L162V greatly benefit from sterols intake. APOA5-C56G-Ser19Trp GG homozygous carriers lowered their TGs more than CG heterozygote carriers (P = 0.003). TT homozygous carriers of gene LIPC C-514T experienced an increase of TGs. Conclusions: Further studies are needed to establish which genotype combinations is the most protective against hypertriglyceridemia.


How to cite this article:
San Mauro Martin I, Blumenfeld Olivares JA, Vilar EG, Ciudad Cabañas MJ, Collado Yurrita L. Modulation of plasma triglycerides concentration by sterol-based treatment in subjects carrying specific genes.Res Cardiovasc Med 2019;8:69-75


How to cite this URL:
San Mauro Martin I, Blumenfeld Olivares JA, Vilar EG, Ciudad Cabañas MJ, Collado Yurrita L. Modulation of plasma triglycerides concentration by sterol-based treatment in subjects carrying specific genes. Res Cardiovasc Med [serial online] 2019 [cited 2019 Dec 13 ];8:69-75
Available from: http://www.rcvmonline.com/article.asp?issn=2251-9572;year=2019;volume=8;issue=3;spage=69;epage=75;aulast=San;type=0