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ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 3  |  Page : 69-75

Modulation of plasma triglycerides concentration by sterol-based treatment in subjects carrying specific genes


1 Research Centers in Nutrition and Health, Madrid, Spain
2 Pediatric Unit, El Escorial Hospital, San Lorenzo de El Escorial, Madrid, Spain
3 Department of Medicine, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain

Correspondence Address:
Dr. Ismael San Mauro Martin
Research Centers in Nutrition and Health, Paseo De La Habana, 43, Madrid 28036
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/rcm.rcm_10_19

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Introduction: Genetic load may indirectly influence on cardiovascular risk. This work aimed to analyze the influence of polymorphisms (APOA5 C56G-Ser19Trp, Prothrombin-G20210A, F5 Arg506Gln, MTHFR-C677T, LIPC-C-514T, LPA-I4300M, PPAR_ALPHA-L162V, APOA5-1131T > C, APOE-APOE2/3/4, and APOE-APOE2,3,4) in plasma triglyceride (TG) levels of patients ingesting plant sterols. Materials and Methods: Double-blind, crossover, controlled clinical trial was performed in 45 individuals (25 women). About 2.24 g sterols in milk and placebo milk were ingested daily during 3 weeks each, separated by a 2-week washout period. Blood draws and saliva genomic DNA was extracted. Results: APOA5-C56G-Ser19Trp, MTHFR-C677T, and PPAR_ALPHA-L162V greatly benefit from sterols intake. APOA5-C56G-Ser19Trp GG homozygous carriers lowered their TGs more than CG heterozygote carriers (P = 0.003). TT homozygous carriers of gene LIPC C-514T experienced an increase of TGs. Conclusions: Further studies are needed to establish which genotype combinations is the most protective against hypertriglyceridemia.


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